Conceptual principles of geospatial data geoinformation integration for administrative and economic management of transport infrastructure facilities

In the article publications have been analyzed and summarized on this topic: studied the experience of implementing building information models and geographic information models for administrative and economic management of transport infrastructure facilities on the example of the regional airport activity. After the stage of collecting geospatial data from various sources and sensors, the data is imported into CAD-systems or GIS-systems. Different software products are used to work with both of these models. The processes of data organization in the process of creating building information models and geographic information models differ to some extent. The issues of integration of such models are not yet fully addressed and need to be addressed. In the process of integration of spatial data, solutions to the integration of semantics, topology, formats and standards of geospatial data are needed. An important task is to develop and study the experience of creating software modules that allow you to integrate BIM-models into geographic information systems. Based on the research, it is established that the current area of research is the development of technologies that allow the generation of information from BIM and GIS to create a more interconnected infrastructure. The integration of BIM and GIS information to create a spatial data infrastructure (SDI) is a perspective direction

Algorithm for calculating the normative area of an industrial enterprise land plot

In the article, the problem of finding justified approaches aimed at achieving sustainable development of urban land use is presented. In Ukraine, as in many post-Soviet countries of Eastern Europe, the transition to market relations has led to a change in production technologies, a reduction in the capacity or the termination of the functioning of industrial enterprises within settlements, but the parameters of land use remained unchanged. However, today, most of the especially large cities face the problem of lack of available land for its normal development. There are trends in the reduction of green zones and building compaction, etc. Based on the results of the established sizes of normative land plots, tax regulation of land use it is proposed to levy a tax in a fivefold amount for a portion of the land plots granted to enterprises, institutions and organizations (except agricultural land) exceeding the standards of land allotment. In the case of the excess of establishing territory for enterprises, institutions and organizations and refusal to pay increased tax, it is possible to optimize the land use by means of an equivalent exchange. Based on the results of the conducted studies it was established that when determining the area of a land plot for an industrial enterprise, the main technical characteristic is its capacity. Modelling is carried out on the basis of data on typical sizes of land plots and enterprise capacities. It is established that a linear regression reliably approximates the dependence of the area on the capacity of the enterprise according to calculations. A detailed analysis shows that for low-capacity enterprises their area will be more reliably determined by non- linear dependence

Fundamental social motives measured across forty-two cultures in two waves

How does psychology vary across human societies? The fundamental social motives framework adopts an evolutionary approach to capture the broad range of human social goals within a taxonomy of ancestrally recurring threats and opportunities. These motives—self-protection, disease avoidance, affiliation, status, mate acquisition, mate retention, and kin care—are high in fitness relevance and everyday salience, yet understudied cross-culturally. Here, we gathered data on these motives in 42 countries (N = 15,915) in two cross-sectional waves, including 19 countries (N = 10,907) for which datawere gathered in both waves. Wave 1 was collected from mid-2016 through late 2019 (32 countries, N = 8,998; 3,302 male, 5,585 female; Mage = 24.43, SD = 7.91). Wave 2 was collected from April through November 2020, during the COVID-19 pandemic (29 countries, N = 6,917; 2,249 male, 4,218 female; Mage = 28.59, SD = 11.31). These data can be used to assess differences and similarities in people’s fundamental social motives both across and within cultures, at different time points, and in relation to other commonly studied cultural indicators and outcomes

A systematic justification of the decision-making scheme in planning the rational use of disturbed lands in Ukraine

The purpose of this work is to justify the need to develop a set of solutions for the organization of the step-by-step planning of rational use of disturbed lands. Currently, environmental problems have worsened due to the closure of mining enterprises, which has led to an urgent need for a scientific approach to the environmental remediation of mining regions and their future rational use and evaluation. The implementation of such approaches can be largely achieved through the creation of improved natural and anthropogenic landscapes on disturbed lands. As a result of the research, the procedure and sequence for the development of rational use of technologically disturbed lands have been formed. This procedure and stages of work performance will provide an opportunity for their reuse, as well as systematize the activities of local government bodies. The criteria for choosing the direction of the technogenic landscape transformation in Ukraine, which are based on the prevention of undesirable, uncontrollable processes of natural and technogenic origin have been formed. The process of the technogenic landscape transformation should be based on the use of potential opportunities and trends inherent in nature itself. The studies on the rational use of disturbed lands in order to adapt them to reuse and prospective use has shown that lands formed as a result of mining can be used for both recreation and industrial development. Complex schemes of sequential actions in the organization of works on the rational use of lands have been develope

Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A

Alzheimer’s disease (AD) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. A combination of genetic, epigenetic and environmental triggers is widely accepted to be responsible for the onset and development of AD. Accumulating evidence shows that oxidative stress and dysregulation of energy metabolism play an important role in AD pathogenesis, leading to neuronal dysfunction and death. Redox-induced protein modifications have been reported in the brain of AD patients, indicating excessive oxidative damage. Coenzyme A (CoA) is essential for diverse metabolic pathways, regulation of gene expression and biosynthesis of neurotransmitters. Dysregulation of CoA biosynthesis in animal models and inborn mutations in human genes involved in the CoA biosynthetic pathway have been associated with neurodegeneration. Recent studies have uncovered the antioxidant function of CoA, involving covalent protein modification by this cofactor (CoAlation) in cellular response to oxidative or metabolic stress. Protein CoAlation has been shown to both modulate the activity of modified proteins and protect cysteine residues from irreversible overoxidation. In this study, immunohistochemistry analysis with highly specific anti-CoA monoclonal antibody was used to reveal protein CoAlation across numerous neurodegenerative diseases, which appeared particularly frequent in AD. Furthermore, protein CoAlation consistently co-localized with tau-positive neurofibrillary tangles, underpinning one of the key pathological hallmarks of AD. Double immunihistochemical staining with tau and CoA antibodies in AD brain tissue revealed co-localization of the two immunoreactive signals. Further, recombinant 2N3R and 2N4R tau isoforms were found to be CoAlated in vitro and the site of CoAlation mapped by mass spectrometry to conserved cysteine 322, located in the microtubule binding region. We also report the reversible H2O2-induced dimerization of recombinant 2N3R, which is inhibited by CoAlation. Moreover, CoAlation of transiently expressed 2N4R tau was observed in diamide-treated HEK293/Pank1β cells. Taken together, this study demonstrates for the first time extensive anti-CoA immunoreactivity in AD brain samples, which occurs in structures resembling neurofibrillary tangles and neuropil threads. Covalent modification of recombinant tau at cysteine 322 suggests that CoAlation may play an important role in protecting redox-sensitive tau cysteine from irreversible overoxidation and may modulate its acetyltransferase activity and functional interactions

Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A

Alzheimer’s disease (AD) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. A combination of genetic, epigenetic and environmental triggers is widely accepted to be responsible for the onset and development of AD. Accumulating evidence shows that oxidative stress and dysregulation of energy metabolism play an important role in AD pathogenesis, leading to neuronal dysfunction and death. Redox-induced protein modifications have been reported in the brain of AD patients, indicating excessive oxidative damage. Coenzyme A (CoA) is essential for diverse metabolic pathways, regulation of gene expression and biosynthesis of neurotransmitters. Dysregulation of CoA biosynthesis in animal models and inborn mutations in human genes involved in the CoA biosynthetic pathway have been associated with neurodegeneration. Recent studies have uncovered the antioxidant function of CoA, involving covalent protein modification by this cofactor (CoAlation) in cellular response to oxidative or metabolic stress. Protein CoAlation has been shown to both modulate the activity of modified proteins and protect cysteine residues from irreversible overoxidation. In this study, immunohistochemistry analysis with highly specific anti-CoA monoclonal antibody was used to reveal protein CoAlation across numerous neurodegenerative diseases, which appeared particularly frequent in AD. Furthermore, protein CoAlation consistently co-localized with tau-positive neurofibrillary tangles, underpinning one of the key pathological hallmarks of AD. Double immunihistochemical staining with tau and CoA antibodies in AD brain tissue revealed co-localization of the two immunoreactive signals. Further, recombinant 2N3R and 2N4R tau isoforms were found to be CoAlated in vitro and the site of CoAlation mapped by mass spectrometry to conserved cysteine 322, located in the microtubule binding region. We also report the reversible H2O2-induced dimerization of recombinant 2N3R, which is inhibited by CoAlation. Moreover, CoAlation of transiently expressed 2N4R tau was observed in diamide-treated HEK293/Pank1β cells. Taken together, this study demonstrates for the first time extensive anti-CoA immunoreactivity in AD brain samples, which occurs in structures resembling neurofibrillary tangles and neuropil threads. Covalent modification of recombinant tau at cysteine 322 suggests that CoAlation may play an important role in protecting redox-sensitive tau cysteine from irreversible overoxidation and may modulate its acetyltransferase activity and functional interactions

Family still matters: Human social motivation across 42 countries during a global pandemic

The COVID-19 pandemic caused drastic social changes for many people, including separation from friends and coworkers, enforced close contact with family, and reductions in mobility. Here we assess the extent to which people's evolutionarily-relevant basic motivations and goals-fundamental social motives such as Affiliation and Kin Care-might have been affected. To address this question, we gathered data on fundamental social motives in 42 countries (N = 15,915) across two waves, including 19 countries (N = 10,907) for which data were gathered both before and during the pandemic (pre-pandemic wave: 32 countries, N = 8998; 3302 male, 5585 female; M age  = 24.43, SD = 7.91; mid-pandemic wave: 29 countries, N = 6917; 2249 male, 4218 female; M age  = 28.59, SD = 11.31). Samples include data collected online (e.g., Prolific, MTurk), at universities, and via community sampling. We found that Disease Avoidance motivation was substantially higher during the pandemic, and that most of the other fundamental social motives showed small, yet significant, differences across waves. Most sensibly, concern with caring for one's children was higher during the pandemic, and concerns with Mate Seeking and Status were lower. Earlier findings showing the prioritization of family motives over mating motives (and even over Disease Avoidance motives) were replicated during the pandemic. Finally, well-being remained positively associated with family-related motives and negatively associated with mating motives during the pandemic, as in the pre-pandemic samples. Our results provide further evidence for the robust primacy of family-related motivations even during this unique disruption of social life

Publisher Correction: Fundamental social motives measured across forty-two cultures in two waves

In the html version of this article the affiliation details for Marco Antonio Correa Varella were incorrectly given as ‘eduLab21, Ayrton Senna Institute, São Paulo, 05423-040, Brazil’, but should have been ‘Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, 05508-030, Brazil’. This has now been corrected in the HTML version of the Article. The PDF version of the Article was correct at the time of publication